| 2021-11-02 17:00:44November 2, 2021 | MACC  | 17:00:445:00 pm |  Missouri Baptist JV | MACC Activity Center | Preview |
| 2021-11-05 17:00:09November 5, 2021 | MACC | 17:00:095:00 pm |  John Wood | MACC Activity Center | Preview |
| 2021-11-06 17:00:10November 6, 2021 | MACC | 17:00:105:00 pm |  Iowa Western | MACC Activity Center | Preview |
| 2021-11-09 17:00:09November 9, 2021 | MACC | 17:00:095:00 pm |  Central Methodist JV | MACC Activity Center | Preview |
| 2021-11-12 17:00:34November 12, 2021 | Vincennes  | 17:00:345:00 pm | MACC | Poplar Bluff, MO | Preview |
| 2021-11-13 13:00:01November 13, 2021 | Rend Lake  | 13:00:011:00 pm | MACC | Poplar Bluff, MO | Preview |
| 2021-11-19 15:00:56November 19, 2021 | Three Rivers  | 15:00:563:00 pm | MACC | Park Hills, MO | Preview |
| 2021-11-20 13:00:51November 20, 2021 | Jefferson | 13:00:511:00 pm | MACC | Park Hills, MO | Preview |
| 2021-11-23 17:00:16November 23, 2021 | MACC | 17:00:165:00 pm |  Metropolitan CC | MACC Activity Center | Preview |
| 2021-11-26 17:00:56November 26, 2021 | MACC | 17:00:565:00 pm |  Rock Valley | MACC Activity Center | Preview |
| 2021-11-27 17:00:13November 27, 2021 | MACC | 17:00:135:00 pm |  ASU-Midsouth | MACC Activity Center | Preview |
| 2021-12-03 19:00:03December 3, 2021 | MACC | 19:00:037:00 pm |  Mineral Area | MACC Activity Center | Preview |
| 2021-12-04 17:00:46December 4, 2021 | MACC | 17:00:465:00 pm |  Crowder | MACC Activity Center | Preview |
| 2021-12-05 17:00:53December 5, 2021 | MACC | 17:00:535:00 pm |  State Fair | MACC Activity Center | Preview |
| 2021-12-12 17:00:54December 12, 2021 | Wabash Valley  | 17:00:545:00 pm | MACC | St. Louis, MO | Preview |
| 2021-12-16 17:00:12December 16, 2021 | MACC | 17:00:125:00 pm |  Illinois Central CC | MACC Activity Center | Preview |
| 2022-01-05 17:00:07January 5, 2022 | Vincennes | 17:00:075:00 pm | MACC | Vincennes, Indiana | Preview |
| 2022-01-08 17:00:16January 8, 2022 | MACC | 17:00:165:00 pm |  St. Louis CC | MACC Activity Center | Preview |
| 2022-01-15 17:00:39January 15, 2022 | Mineral Area | 17:00:395:00 pm | MACC | Park Hills, MO | Preview |
| 2022-01-19 17:00:33January 19, 2022 | MACC | 17:00:335:00 pm | Three Rivers | MACC Activity Center | Preview |
| 2022-01-22 14:00:25January 22, 2022 | Crowder | 14:00:252:00 pm | MACC | Neosho, MO | Preview |
| 2022-01-26 17:00:45January 26, 2022 | MACC | 17:00:455:00 pm | State Fair | MACC Activity Center | Preview |
| 2022-01-29 14:00:24January 29, 2022 | Jefferson | 14:00:242:00 pm | MACC | Hillsboro, MO | Preview |
| 2022-02-02 17:00:38February 2, 2022 | Metropolitan CC | 17:00:385:00 pm | MACC | Kansas City, MO | Preview |
| 2022-02-05 17:00:57February 5, 2022 | MACC | 17:00:575:00 pm | Mineral Area | MACC Activity Center | Preview |
| 2022-02-09 17:00:42February 9, 2022 | Three Rivers | 17:00:425:00 pm | MACC | Poplar Bluff, MO | Preview |
| 2022-02-12 17:00:27February 12, 2022 | MACC | 17:00:275:00 pm | Crowder | MACC Activity Center | Preview |
| 2022-02-16 17:00:22February 16, 2022 | MACC | 17:00:225:00 pm | Jefferson | MACC Activity Center | Preview |
| 2022-02-19 17:00:37February 19, 2022 | State Fair | 17:00:375:00 pm | MACC | Sedalia, MO | Preview |
| 2022-02-22 18:00:39February 22, 2022 | MACC | 18:00:396:00 pm |  Missouri Valley JV | MACC Activity Center | Preview |